Akt Inhibitor VI; Akt-in

Biochem/physiol Actions

Cell permeable: no

Kd ~18 µM in binding to Akt-PH domain

Reversible: yes

Product does not compete with ATP.

Primary TargetAkt

General description

A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (K_d ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.

A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL_10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (K_d ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hiromura, M., et al. 2004. J. Biol. Chem.279, 53407.

Packaging

2 mg in Plastic ampoule

Packaged under inert gas

Physical form

Supplied as an acetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.r>

Sequence

H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH

Warning

Toxicity: Carcinogenic / Teratogenic (D)